LEADSPHERE™ Lyophilization Technology ★
| Numerous advantages of freeze-drying reagents have been documented, with the most significant one of all being the ability to sustain the ingredients‘ activities at room temperature. This process requires highly professional and repetitionary-condition optimizations. At Leadgene, our innovative LEADSPHERE™ lyophilization technology serves as a platform to ease the development of your reagents in lyophilized and in stable sphere format while maintaining the components’ bioactive condition at room temperature for at least 12 months. |
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What are the benefits of the freeze-drying format? ● No more cooling system ● Reduced assay turnaround time ● Ease of handling for IVD tests ● Ideal for point-of-care testing |
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Why choose LEADSPHERE™ technology? ● Sphere format to ease aliquot ● Assure activities of your biomolecules ● Work with 20 μl mixture (~ 3.3 mm diameter) or more ● Fully custom process and customer support |
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Molecules that can be used in LEADSPHERE™ technology: Antibodies, Proteins, Enzymes, Chemicals, PCR Mixture
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Employing an endopeptidase, LEADSPHERE™ Proteinase K, used for DNA or RNA sample preparation by digesting proteins and inactivating ribonuclease is a notable example of LEADSPHERE™ lyophilization technology. LEADSPHERE™ Proteinase K, provided in a lyophilized sphere format, not only has all the advantages of LEADSPHERE™ technology, such as product stability and high-temperature tolerance, but it also has other benefits in multiple aspects: 1. Supports “pick and place” automation system for commercial-scale production. 2. Reduces pipetting step and simplifies protocols for end users. 3. Allows direct mixing with various sample types such as saliva, blood, or samples in trace quantities. |
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LEADSPHERE™ Proteinase K completely digests bovine serum albumin (BSA). BSA was mixed with Proteinase K at 37°C for an hour, and subsequently analyzed by SDS-PAGE.
Lane 1. 2 μg of BSA Lane 2. 16 μg of BSA with 0.01 μg of Proteinase K Lane 3. 16 μg of BSA with 0.1 μg of Proteinase K Lane 4. 16 μg of BSA with 1 μg of Proteinase K |
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LEADSPHERE™ Proteinase K formulation is fine-tuned for direct mixing with and digestion of saliva. LEADSPHERE™ Proteinase K is generated with ISO13485 quality management system specifically for medical devices, and has been thoroughly used in applications to identify viruses, including SARS-CoV-2. |
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Contact us at info@leadgene.com.tw to discuss your project.
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