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Leadgene Leadgene
Human MMP7 (proenzyme), His Tag, E. coli
Catalog Number

LDG055PHE

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  • Specifications
    • Species of Origin

      Human

      Expression System

      Escherichia coli

    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 8.0.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 30.47 kDa.
      The protein migrates as 26 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      Matrix metalloproteinase-7 proenzyme (proMMP-7) is a 30.47 kDa matrix metalloproteinases with 273 amino acid residues. MMP-7 restricted production by normal mucosal and exocrine gland epithelial cells, as well as by carcinoma cells. Functionally, it involved breakdown of extracellular matrix (casein, gelatins of types I, III, IV, and V, and fibronectin) in normal physiological processes and disease processes. MMP-7 is contributed to early tumor development during carcinogenesis. proMMP7 activation by trypsin occurs via an intermediate cleaved at Lys50-Asn51.

      Synonyms

      Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase, Matrilysin

    • Uniprot ID

      #P09237

      Sequence Note

      Met1-Lys276

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant human MMP7 (proenzyme).

    SDS-PAGE analysis of recombinant human MMP7 (proenzyme).

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  • Datasheet & Documents
    MSDS
    Manual
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