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Leadgene Leadgene
Human M-CSF, His Tag, HEK293
Catalog Number

LDG026PHM

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  • Specifications
    • Species of Origin

      Human

      Expression System

      HEK293

    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 19.21 kDa.
      The protein migrates as 20 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      LAG-3, or Lymphocyte-activation gene 3, is a protein receptor expressed on the surface of certain immune cells, notably T cells and natural killer cells. It plays a pivotal role in regulating immune responses by inhibiting the activation and proliferation of T cells. LAG-3 is involved in immune tolerance and suppression, making it a promising target for immunotherapy in various diseases, including cancer and autoimmune disorders. Blocking LAG-3 can enhance anti-tumor immune responses, while agonists can suppress excessive immune activation. Studying LAG-3 function provides insights into immune regulation and therapeutic strategies.

      Synonyms

      CSF-1, Lanimostim, Proteoglycan macrophage colony-stimulating factor (PG-M-CSF)

    • Uniprot ID

      P09603

      Sequence Note

      Glu33-Gln181

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

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  • Datasheet & Documents
    MSDS
    Manual
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    1

Disclaimer:For Research Use or Further Manufacturing Only.

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