Human IL-6R, His Tag, CHO

Catalog Number

LDG027PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    CHO

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >90% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 39.35 kDa.
    The protein migrates as 55-65 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    IL-6R (Interleukin-6 Receptor) protein is a transmembrane receptor that binds to interleukin-6 (IL-6), a pro-inflammatory cytokine. Upon ligand binding, IL-6R activates downstream signaling cascades involved in immune responses, inflammation, and acute-phase reactions. IL-6R exists in two forms: membrane-bound (mIL-6R) and soluble (sIL-6R). Dysregulation of IL-6R signaling is implicated in various inflammatory diseases and cancers. Targeting IL-6R signaling, either by blocking IL-6R or IL-6, has emerged as a therapeutic strategy for treating inflammatory disorders and cancers. Understanding IL-6R's roles in immune regulation and disease pathogenesis is crucial for developing targeted therapies.

    Synonyms

    Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80 (gp80), Soluble interleukin-6 receptor subunit alpha, CD126

  • Uniprot ID

    NP_000556.1

    Sequence Note

    Met1-Ser232

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human IL-6R.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.