Leadgene Leadgene
Human IL-6R, His Tag, CHO
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  • Specifications
    • Species of Origin


      Expression System


    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >90% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 39.35 kDa.
      The protein migrates as 55-65 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      IL-6R (Interleukin-6 Receptor) protein is a transmembrane receptor that binds to interleukin-6 (IL-6), a pro-inflammatory cytokine. Upon ligand binding, IL-6R activates downstream signaling cascades involved in immune responses, inflammation, and acute-phase reactions. IL-6R exists in two forms: membrane-bound (mIL-6R) and soluble (sIL-6R). Dysregulation of IL-6R signaling is implicated in various inflammatory diseases and cancers. Targeting IL-6R signaling, either by blocking IL-6R or IL-6, has emerged as a therapeutic strategy for treating inflammatory disorders and cancers. Understanding IL-6R's roles in immune regulation and disease pathogenesis is crucial for developing targeted therapies.


      Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80 (gp80), Soluble interleukin-6 receptor subunit alpha, CD126

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant human IL-6R.

    SDS-PAGE analysis of recombinant human IL-6R.

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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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