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Species of Origin
Human
Expression System
CHO
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Affinity Tag
His Tag (C-term)
Storage Buffer
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
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Purity
>90% as determined by SDS-PAGE analysis.
Molecular weight
The protein has a calculated MW of 55.73 kDa.
The protein migrates as 30-72 kDa under reducing condition (SDS-PAGE analysis). -
Endotoxin Level
<0.1 EU per 1 μg of the protein by the LAL method.
Form
Lyophilized
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Specifications
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Background
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Background
Angiopoietin-2 (Ang-2) protein is a ligand for the Tie-2 receptor, crucial for angiogenesis and vascular remodeling. Unlike Angiopoietin-1 (Ang-1), Ang-2 destabilizes blood vessels, promoting endothelial cell apoptosis and vascular leakage. Ang-2 expression is upregulated during inflammation and vascular remodeling, contributing to pathological angiogenesis in diseases like cancer and retinopathy. Targeting Ang-2 signaling shows promise in inhibiting tumor growth and metastasis. However, its precise roles in angiogenesis and disease progression are still under investigation. Understanding Ang-2's functions provides insights into vascular biology and potential therapeutic strategies for angiogenesis-related disorders.
Synonyms
Angiopoietin-2
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Uniprot ID
O15123
Sequence Note
Met1-Phe496
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Instruction
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Reconstitution
It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
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Stability & Storage
This product is stable after storage at:
- -20°C for 12 months in lyophilized state from date of receipt.
- -20°C or -80°C for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
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Review
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Publication
There are currently no publications. Use the link below to let us know.
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Datasheet & Documents
1/1
Disclaimer：For Research Use or Further Manufacturing Only.
