Leadgene Leadgene
Mouse VISTA, His Tag, CHO
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  • Specifications
    • Species of Origin


      Expression System


    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 18.57 kDa.
      The protein migrates as 30-42 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      VISTA (V-domain Ig suppressor of T cell activation) protein, a member of the B7 family, acts as a negative regulator of T cell activation and inflammation. Primarily expressed on myeloid cells and T cells, VISTA inhibits T cell proliferation and cytokine production upon engagement with its receptor. Its immunosuppressive role is crucial in maintaining immune tolerance and preventing excessive inflammation. However, in cancer, VISTA overexpression can contribute to immune evasion by tumors. Understanding VISTA's immunomodulatory functions is pivotal for developing targeted immunotherapies to enhance anti-tumor immune responses while avoiding autoimmune reactions.


      Platelet receptor Gi24, V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant mouse VISTA.

    SDS-PAGE analysis of recombinant mouse VISTA.

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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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