Mouse Trop-2, His Tag, HEK293

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Catalog Number

LDG028PMM

Datasheet

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• Specifications

  • Species of Origin

    Mouse

    Expression System

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 33 kDa.
    The protein migrates as 35-45 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The ED50 for this effect is <20 μg/mL.

    Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    Trop-2, also known as TACSTD2 (Tumor-Associated Calcium Signal Transducer 2), is a cell surface glycoprotein encoded by the TACSTD2 gene. It is widely expressed in various epithelial tissues and overexpressed in many cancers, including breast, lung, colorectal, and pancreatic cancers. Trop-2 plays a crucial role in promoting tumor growth, metastasis, and resistance to therapy, making it an attractive target for cancer diagnosis and treatment. Its involvement in cell proliferation, migration, and survival pathways underscores its significance as a potential biomarker for disease prognosis and a therapeutic target. Research efforts are ongoing to develop targeted therapies, such as monoclonal antibodies and antibody-drug conjugates, aimed at inhibiting Trop-2 activity and improving cancer treatment outcomes. Understanding the complex roles of Trop-2 in cancer biology holds promise for advancing precision medicine strategies and improving patient care.

    Synonyms

    Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2

  • Uniprot ID

    Q8BGV3

    Sequence Note

    Met1-Gly270

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  Activity analysis of recombinant Mouse Trop-2, His Tag, HEK293.
  Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The ED50 for this effect is <20 μg/mL.

  SDS-PAGE analysis of recombinant Mouse Trop-2.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.