Leadgene Leadgene
Mouse TNFR-1, His Tag, CHO
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  • Specifications
    • Species of Origin


      Expression System


    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 21.15 kDa.
      The protein migrates as 30-40 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      TNFR-1, or Tumor Necrosis Factor Receptor 1, is a transmembrane protein receptor found on the surface of various cell types. It serves as a key mediator in the signaling pathway activated by Tumor Necrosis Factor-alpha (TNF-alpha), a cytokine involved in inflammation and immune response regulation. Upon binding with TNF-alpha, TNFR-1 triggers downstream signaling cascades that regulate cell survival, apoptosis, and inflammation. Dysregulation of TNFR-1 signaling has been implicated in autoimmune diseases, inflammatory conditions, and cancer. Understanding the molecular mechanisms of TNFR-1 activation is crucial for developing targeted therapies for diseases involving TNF-alpha dysregulation.


      Tumor necrosis factor receptor 1 (TNF-R1), Tumor necrosis factor receptor type I (TNF-RI; TNFR-I), p55, p60, CD120a

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant mouse TNFR-1.

    SDS-PAGE analysis of recombinant mouse TNFR-1.

    Total   (1)
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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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