Leadgene Leadgene
Mouse PD-L2, His Tag, CHO
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  • Specifications
    • Species of Origin


      Expression System


    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 23.35 kDa.
      The protein migrates as 30-40 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      PD-L2, or Programmed Death-Ligand 2, is a transmembrane protein expressed on antigen-presenting cells and non-hematopoietic cells. It functions as a ligand for the programmed cell death protein 1 (PD-1) receptor on T cells, delivering inhibitory signals that regulate immune responses. PD-L2 engagement with PD-1 contributes to T cell exhaustion, immune tolerance, and evasion of immune surveillance by tumors. Blockade of the PD-L2/PD-1 pathway has emerged as a promising strategy in cancer immunotherapy, enhancing anti-tumor immune responses. Understanding PD-L2's role in immune regulation is essential for developing targeted therapies for cancer and autoimmune diseases.


      PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC (B7-DC), CD273

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant mouse PD-L2.

    SDS-PAGE analysis of recombinant mouse PD-L2.

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  • Datasheet & Documents

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