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Leadgene Leadgene
Mouse PD-1, His Tag, HEK293
Catalog Number

LDG004PMM

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  • Specifications
    • Species of Origin

      Mouse

      Expression System

      HEK293

    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 16.95 kDa.
      The protein migrates as 25-40 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      PD-1, or programmed cell death protein 1, is a cell surface receptor protein primarily expressed on activated T cells. It plays a pivotal role in regulating immune responses by interacting with its ligands, PD-L1 and PD-L2, which are often expressed on cancer cells and antigen-presenting cells. Binding of PD-1 to its ligands leads to inhibition of T cell activation and proliferation, suppressing immune responses against cancer cells and contributing to immune evasion. Blocking the PD-1/PD-L1 interaction with therapeutic antibodies enhances T cell activity, making PD-1 inhibitors a promising approach in cancer immunotherapy.

      Synonyms

      CD279, Pdcd1

    • Uniprot ID

      NP_032824

      Sequence Note

      Met1-Gln167

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

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  • Datasheet & Documents
    MSDS
    Manual
    1
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    1

Disclaimer:For Research Use or Further Manufacturing Only.

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