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Leadgene Leadgene
Mouse CTLA-4, His Tag, HEK293
Catalog Number

LDG005PMM

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  • Specifications
    • Species of Origin

      Mouse

      Expression System

      HEK293

    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 14.62 kDa.
      The protein migrates as 20-25 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      CTLA-4 is a protein belonging to the immunoglobulin superfamily and the CD28 receptor family. It interacts with CD80 (B7-1) and CD86 (B7-2) to transmit inhibitory signals to T cells, in contrast to CD28, which sends stimulatory signals. This receptor is also found within regulatory T cells, where it plays a vital role in their functions. CTLA-4 is a key regulator of T cell activation, making it an appealing candidate for autoimmune disease therapy and cancer immunotherapy. Recent evidence further highlights its importance in the function and balance of regulatory T cells (Treg).

      Synonyms

      Cytotoxic T-lymphocyte-associated antigen 4, CD152

    • Uniprot ID

      NP_033973

      Sequence Note

      Met1-Phe162

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

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  • Datasheet & Documents
    MSDS
    Manual
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    1

Disclaimer:For Research Use or Further Manufacturing Only.

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