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Leadgene Leadgene
Mouse Clec9a, Fc Tag, CHO
Catalog Number

LDG014PMM

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  • Specifications
    • Species of Origin

      Mouse

      Expression System

      CHO

    • Affinity Tag

      Fc Tag (N-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

    • Purity

      >90% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 49.7 kDa.
      The protein migrates as 55-65 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      Clec9a, also known as DNGR-1 (Dendritic Cell Natural Killer lectin Group Receptor-1), is a type II transmembrane protein predominantly expressed on dendritic cells. It serves as a pattern recognition receptor involved in the detection of necrotic cell death. Upon ligand binding, Clec9a triggers dendritic cell activation and antigen presentation, promoting immune responses against pathogens and cancer. Its specificity for necrotic cells distinguishes it from other receptors involved in immune surveillance. Harnessing Clec9a's targeting abilities shows potential for developing vaccines and immunotherapies against infectious diseases and cancer, highlighting its significance in immune regulation and therapeutic development.

      Synonyms

      C-type lectin domain family 9 member A, Dendritic cell natural killer lectin group receptor 1, CD370, Dngr-1

    • Uniprot ID

      NP_001192292.1

      Sequence Note

      Lys57-Ile264

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

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  • Datasheet & Documents
    MSDS
    Manual
    1
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    1

Disclaimer:For Research Use or Further Manufacturing Only.

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