Leadgene Leadgene
Mouse CAIX, His Tag, CHO
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  • Specifications
    • Species of Origin


      Expression System


    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 39.66 kDa.
      The protein migrates as 42 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      CAIX (Carbonic Anhydrase IX) protein, a transmembrane enzyme, is overexpressed in various solid tumors, including renal cell carcinoma. It catalyzes the reversible hydration of carbon dioxide to bicarbonate ions and protons, playing a crucial role in pH regulation and acid-base balance within the tumor microenvironment. CAIX facilitates tumor cell survival, migration, and invasion by maintaining an acidic extracellular pH and promoting angiogenesis. Its selective expression in tumor tissues makes CAIX an attractive target for cancer therapy. Inhibiting CAIX activity disrupts tumor growth and metastasis, highlighting its significance as a diagnostic and therapeutic biomarker in oncology.


      Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX)), Membrane antigen MN homolog

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant mouse CAIX.

    SDS-PAGE analysis of recombinant mouse CAIX.

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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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