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Species of Origin
Human
Expression System
Escherichia coli
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Affinity Tag
Tag Free
Storage Buffer
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
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Purity
>97% as determined by SDS-PAGE analysis.
Molecular weight
The protein has a calculated MW of 12.96 kDa.
The protein migrates as 13-17 kDa under reducing condition (SDS-PAGE analysis). -
Activity
Measure by its ability to inhibit the proliferation of mouse MPC-11 cells. The ED₅₀ for this effect is <10 ng/mL. The specific activity of recombinant human Activin A is approximately >1.0 x 10³ IU/mg.
Endotoxin Level
<0.05 EU per 1 µg of the protein by the LAL method.
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Mycoplasma
Negative
Form
Lyophilized
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Default
Negative
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Specifications
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Background
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Background
Activin is the member of the TGF beta superfamily of cytokines. The current understanding of Activin A is classified as a hormone, a growth factor, and a cytokine. Depending on the different cell type, that overexpression of Activin A can either inhibit or promote cells division. There are important implications for tumor biology. Activin A also increase joint inflammation in rheumatoid arthritis (RA) and induces pathogenic mechanisms in the respiratory system.
Synonyms
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein , EDF
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Sequence Note
Gly311-Ser426
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Instruction
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Reconstitution
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.5 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
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Stability & Storage
This product is stable after storage at:
- -20°C for 12 months in lyophilized state from date of receipt.
- -20°C or -80°C for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Manufacturing Specifications
LeadGMP® recombinant proteins are manufactured in ISO 13485:2016 and GMP certified facility. The processes include:
- Animal-free reagent and laboratory
- Manufactured and tested under GMP guideline
- Testing and traceability of raw material
- Records of the maintenance and equipment calibration
- Personnel training records
- Batch-to-batch consistency
- Documentation of QA control and process changes
- Manufactured and tested under an ISO 13485:2016 certified quality management system
- Stability monitor of product shelf-life
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Image
![SDS-PAGE analysis of LeadGMP® Activin A, Human]()
SDS-PAGE analysis of LeadGMP® Activin A, Human
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Publication
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Datasheet & Documents
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Disclaimer：For Research Use or Further Manufacturing Only.
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