Animal-free reagent and laboratory
Manufactured and tested under GMP guideline
MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT with polyhistidine tag at the C-terminus.
Interleukin-2 (IL-2) is a 15.5 kDa four bundle, immuno-modulatory cytokine which is expressed predominately by antigen-simulated CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and dendritic cells (DC). IL-2 plays a fundamental role in promoting NK cell proliferation, cytotoxicity, and B cells differentiation. IL-2 modulate T cell differentiation programs, promoting naïve CD4+ T cell differentiation into T helper-1 (Th1) and T helper-2 (Th2) cells.
Measure by its ability to induce proliferation in CTLL-2 cells.
The ED50 for this effect is <3 ng/mL.
The specific activity of recombinant human IL-2 is approximately >5 x 106 IU/mg.
Measure by its ability to induce proliferation in NK cells.
The ED50 for this effect is <46 ng/mL.
Lyophilized protein should be stored at -20°C.
This product is stable for one year upon receipt, when handled and stored as instructed.
Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Avoid repeated freeze/thaw cycles.
|IL-2 (Interleukin-2) protein, Human (60701GMP) stimulates the proliferation of CTLL-2 cells. The ED50 is 1.5 ng/mL.|
|IL2 (Interleukin-2) protein, Human (60701GMP) was separated on SDS-PAGE under the reducing condition and visualized by Coomassie Blue staining.|
1. Malek TR. (2008) Annu Rev Immunol. 26: 453-79.
2. Gaffen SL, Liu KD. (2004) Cytokine. 28,3: 109‐23.
3. Varas A et al. (1998) Dev Immunol. 6,1-2: 141-7.
4. Abbas AK et al. (2018) Sci Immunol. 3,25: eaat1482.
*Carriers: 0.1% BSA, 5% HSA or 10% FBS.
60701GMP / 100 μg