Human SIRP Alpha, Fc Tag, CHO

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Catalog Number

LDG103PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    CHO

  • Affinity Tag

    Human IgG1 Fc tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated 63.4 MW of kDa.
    The protein migrates as 65-100 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measured by its ability to support the adhesion of red blood cells, with the ED50 being < 3 μg/mL.

    Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Mycoplasma

    Not detected

    Form

    Lyophilized

• Background

  • Background

    SIRPα is a negative regulator of immune cell activation, interacting with the "don't eat me" signal CD47 on tumor cells. It is being explored in cancer therapy to enhance anti-tumor immunity.

    Synonyms

    Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a

  • Uniprot ID

    P78324

    Sequence Note

    Glu31-Arg370

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  

  Human SIRP Alpha, Fc Tag, CHO (LDG103PHM) supports the adhesion of red blood cells, with the ED50 being < 3 μg/mL.

  

  SDS-PAGE analysis of recombinant human SIRP Alpha.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.