Human Noggin, Fc Tag, CHO

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Catalog Number

LDG169PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    CHO

  • Affinity Tag

    hIgG1 Fc (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 49.11 kDa.
    The protein migrates as 58 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measure by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 cells. The ED₅₀ for this effect is <0.05 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4.

    Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Mycoplasma

    Not detected

    Form

    Lyophilized

• Background

  • Background

    Human Noggin is a secreted protein that inhibits bone morphogenetic proteins (BMPs), such as BMP-2, -4, and -7. It plays a key role in embryonic development, especially in neural and skeletal formation. By blocking BMP signaling, Noggin helps regulate cell differentiation and tissue patterning. Recombinant Human Noggin is commonly used in stem cell research and organoid culture to maintain pluripotency and control differentiation.

    Synonyms

    Noggin, NOG, SYM1, SYNS1, SYNS1A, Symphalangism 1 (Proximal), Synostoses (Multiple) Syndrome 1

  • Uniprot ID

    Q13253

    Sequence Note

    Gln28-Cys232

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  Activity analysis of recombinant Human Noggin, Fc Tag, CHO.
  Measure by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 cells. The ED₅₀ for this effect is <0.05 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4.

  SDS-PAGE analysis of recombinant human Noggin.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.