Human MMP-8, His Tag, CHO

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Catalog Number

LDG145PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    CHO

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 51.94 kDa.
    The protein migrates as 60-75 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    Matrix metalloproteinase-8 (MMP8), also known as neutrophil collagenase, is an enzyme involved in the degradation of extracellular matrix components, particularly type I collagen. It is predominantly expressed in neutrophils and plays a role in tissue remodeling, inflammation, and wound healing. Dysregulation of MMP8 activity has been associated with various pathological conditions, including periodontal disease and cancer.

    Synonyms

    Neutrophil collagenase, EC:3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL

  • Uniprot ID

    P22894

    Sequence Note

    Phe21-Gly467

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  HPLC analysis of recombinant Human MMP-8, His Tag, CHO.
  The purity of Human MMP-8 Protein is greater than 95% as determined by RP-HPLC.

  SDS-PAGE analysis of recombinant human MMP8.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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