Human IL-28B, His Tag, E. coli

Catalog Number

LDG097PHE

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    Escherichia coli

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 8.0.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 25.57 kDa.
    The protein migrates as 21 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measure by its ability to protect HepG2 cells infected with encephalomyocarditis (EMC) virus. The ED₅₀ for this effect is <5 ng/mL.

    Endotoxin Level

    <0.01 EU per 1 µg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    Interleukin-28B (IL-28B, now known as Interferon Lambda 3, IFN-λ3) is a 19.77 kDa member of type III IFN family with 176 amino acid residues. IL-28B is expressed by epithelial tissues. Cytokine with antiviral, antitumor and immunomodulatory activities. Able to activate JAK/STAT signaling pathway via binding its receptor IFNLR1 in epithelial cells.

    Synonyms

    Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, Interferon lambda-3

  • Uniprot ID

    #Q8IZI9

    Sequence Note

    Val22-Val196

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 2 weeks under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human IL-28B.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.