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Species of Origin
Human
Expression System
HEK293
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Affinity Tag
His Tag (C-term)
Storage Buffer
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
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Endotoxin Level
<0.1 EU per 1 μg of the protein by the LAL method.
Form
Lyophilized
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Specifications
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Background
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Background
CTLA-4 is a protein belonging to the immunoglobulin superfamily and the CD28 receptor family. It interacts with CD80 (B7-1) and CD86 (B7-2) to transmit inhibitory signals to T cells, in contrast to CD28, which sends stimulatory signals. This receptor is also found within regulatory T cells, where it plays a vital role in their functions. CTLA-4 is a key regulator of T cell activation, making it an appealing candidate for autoimmune disease therapy and cancer immunotherapy. Recent evidence further highlights its importance in the function and balance of regulatory T cells (Treg).
Synonyms
CD152
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Uniprot ID
P16410
Sequence Note
Lys36-Arg162
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Instruction
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Reconstitution
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
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Stability & Storage
This product is stable after storage at:
- -20°C for 12 months in lyophilized state from date of receipt.
- -20°C or -80°C for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
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Review
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Publication
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Datasheet & Documents
1/1
Disclaimer：For Research Use or Further Manufacturing Only.
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