Human CD22, His Tag, CHO

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Catalog Number

LDG184PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    CHO

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 75.98 kDa.
    The protein migrates as 90-120 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 for this effect is <0.5 μg/mL.

    Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    CD22 is a B-cell-specific transmembrane glycoprotein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It functions as an inhibitory co-receptor that modulates B-cell receptor signaling, maintaining immune tolerance and preventing overactivation. CD22 is an important biomarker and therapeutic target in B-cell malignancies and autoimmune diseases.

    Synonyms

    Cluster of Differentiation 22, Siglec-2, B-cell receptor CD22, BL-CAM, B-lymphocyte cell adhesion molecule

  • Uniprot ID

    P20273

    Sequence Note

    Met1-Arg687

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  Activity analysis of recombinant Human CD22, His Tag, CHO.
  Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 for this effect is <0.5 μg/mL.

  SDS-PAGE analysis of recombinant human CD22 protein.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.