• Does Leadgene provide custom protein, antibody, enzyme, or assay development services?
    Leadgene offers diverse and flexible custom solutions. Our popular service offerings include: ① Gene/peptide synthesis, protein expression, and purification ② Nanobody (VHH), monoclonal, polyclonal, recombinant antibodies, & humanization ③ ELISA kit and lateral flow assay development ④ Enzyme project feasibility assessment and customization If you have other customized project ideas or specific requirements, please feel free to contact us. Our team is dedicated to designing a tailored solution that best fits your needs.
    Does Leadgene provide support for experimental optimization and troubleshooting?
    Our technical team provides troubleshooting support for Leadgene products and custom services. To help us identify the issue more efficiently, please provide the product catalog number, lot number, sample type, experimental workflow, buffer used, concentration, reaction conditions, and any differences between the actual and expected results. Our team will review the information and get back to you as soon as possible.
  • What real-time cell culture monitoring instruments does Leadgene Group provide?
    Leadgene Group's subsidiary, Leadgene Biosolutions, provides two major categories of cell culture and bioprocess research platforms: ① S.NEST 2.0, C.NEST 2.0, and C.BIRD: Designed for cell culture, screening, and process optimization, with primary applications in cell line development, clone screening, culture-condition evaluation, and early-stage bioprocess optimization. ② DolphinQ and DolphinQ Mini: Long-term, real-time cell metabolism monitoring systems focused on analyzing cellular metabolic changes continuously over extended culture periods.
    Which cell culture parameters can be monitored continuously and in real time?
    Leadgene Group’s subsidiary, Leadgene Biosolutions, offers platforms that continuously monitor key physiological and metabolic parameters in real time, including dissolved oxygen (DO), pH, oxygen consumption rate (OCR), and extracellular acidification rate (ECAR). These dynamic measurements allow you to closely monitor cell growth, metabolic health, and subtle changes in culture conditions.
  • How does continuous, non-invasive monitoring differ from conventional endpoint assays?
    Conventional Endpoint Assays: Capture only single, static time points, potentially missing dynamic fluctuations during cell culture. Continuous Non-Invasive Monitoring: Provides continuous time-series data throughout culture, giving you complete visibility into growth trends, metabolic shifts, and critical transition points without disturbing your cells.
    What cell types, culture formats, and research applications are supported?
    Leadgene Group’s subsidiary, Leadgene Biosolutions, offers the NEST series of microbioreactors, which support high-throughput culture in 24-well and 96-well microplates. The systems can be used for cell line development, single-cell clone culture, culture-condition screening, and early-stage bioprocess development and optimization. When paired with DolphinQ or DolphinQ Mini, the systems can also enable continuous monitoring of cellular metabolism throughout the culture period. Based on the selected platform, cell-line characteristics, and experimental design, the Leadgene Biosolutions team can assist in evaluating the appropriate culture format, working volume, culture medium, mixing conditions, and other compatibility requirements.
  • How do I choose the right cell culture monitoring instrument for my experiment?
    The right monitoring instrument depends on your research goals, culture scale, throughput, and target parameters: ① Bioprocess & Culture Optimization: S.NEST, C.NEST, or C.BIRD ② Long-Term Metabolic Monitoring: DolphinQ Series
    What preclinical validation services does Leadgene Group provide?
    Leadgene Group’s subsidiary, SIDSCO, provides integrated preclinical CRO services, including animal disease models, efficacy and safety evaluation, histopathology, molecular and cell-based studies, and customized study design. SIDSCO is a TAF-certified Good Laboratory Practice (GLP) laboratory and has established a Human-Relevant Skin Validation Platform using Reconstructed Human Epidermis (RhE) technology to support studies on skin irritation, skin corrosion, inflammatory responses, aesthetic product development, and skin wound healing.
  • What disease animal models and efficacy studies are available?
    Leadgene Group’s subsidiary, SIDSCO, has established over 15 disease animal models for disease mechanism research, candidate drug efficacy evaluation, and preclinical validation. All studies can be combined with histopathology and biomolecular analyses for comprehensive evaluation: ① Viral Infection Models: Influenza virus, Dengue virus, and enterovirus A71. ② Organ Disease & Fibrosis Models: Unilateral ureteral obstruction (UUO), 5/6 nephrectomy, and bleomycin-induced pulmonary fibrosis. ③ Tumor and liver disease models.
    Can the study design, animal model, and analytical endpoints be customized?
    Leadgene Group’s subsidiary, SIDSCO, can customize preclinical study designs, disease models, and analytical endpoints based on your research objectives and product characteristics. ① Analytical Endpoints: Includes histopathology, cytokines, biomarkers, nucleic acid, and protein analysis. ② Specialized Platform: Features a Human-Relevant Skin Validation Platform utilizing Reconstructed Human Epidermis (RhE) technology for customized studies in skin irritation, corrosion, inflammatory responses, aesthetic product development, and wound healing.