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Leadgene Leadgene
Canine PD-L1 Protein, His Tag, HEK293
Catalog Number

LDG003POM

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  • Overview

    Description

    PD-L1 regulates immune responses by binding to the immunoinhibitory receptor PD-1 on activated T-cells and B-cells. This interaction can suppress T-cell responses by inducing apoptosis and arresting cell-cycle progression. In cancer, PD-L1's role in reducing antigen-specific T cells can promote tumor growth and immune evasion. As a result, PD-L1 is considered as a potential therapeutic target for autoimmune diseases and cancer.

  • Specifications
    • Species of Origin

      Canine

      Expression System

      HEK293 cell

    • Affinity Tag

      His Tag (C-term)

      Storage Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >90% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 26 kDa.
      The protein migrates as 35-45 kDa uder reducing condition (SDS-PAGE analysis).

    • Endotoxin Level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Synonyms

      CD274, B7-H1

      Uniprot ID

      NCBI Reference Sequence: NP_001278901.1

    • Sequence Note

      Phe19-Arg236

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant Canine PD-L1 Protein.

    SDS-PAGE analysis of recombinant Canine PD-L1 Protein.

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  • Datasheet & Documents
    MSDS
    Manual
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