Description
PD-L1 regulates immune responses by binding to the immunoinhibitory receptor PD-1 on activated T-cells and B-cells. This interaction can suppress T-cell responses by inducing apoptosis and arresting cell-cycle progression. In cancer, PD-L1's role in reducing antigen-specific T cells can promote tumor growth and immune evasion. As a result, PD-L1 is considered as a potential therapeutic target for autoimmune diseases and cancer.
Species of Origin
Canine
Expression System
HEK293
Affinity Tag
His Tag (C-term)
Storage Buffer
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Purity
>90% as determined by SDS-PAGE analysis.
Molecular weight
The protein has a calculated MW of 26 kDa.
The protein migrates as 35-45 kDa uder reducing condition (SDS-PAGE analysis).
Endotoxin Level
<0.1 EU per 1 μg of the protein by the LAL method.
Form
Lyophilized
Synonyms
CD274, B7-H1
Uniprot ID
NCBI Reference Sequence: NP_001278901.1
Sequence Note
Phe19-Arg236
Reconstitution
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
Stability & Storage
This product is stable after storage at:
Avoid repeated freeze/thaw cycles.
SDS-PAGE analysis of recombinant Canine PD-L1.
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Disclaimer：For Research Use or Further Manufacturing Only.
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