Human PD-1, His Tag, CHO

Catalog Number

LDG028PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    CHO

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 16.76 kDa.
    The protein migrates as 30-40 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    PD-1, or programmed cell death protein 1, is a cell surface receptor protein primarily expressed on activated T cells. It plays a pivotal role in regulating immune responses by interacting with its ligands, PD-L1 and PD-L2, which are often expressed on cancer cells and antigen-presenting cells. Binding of PD-1 to its ligands leads to inhibition of T cell activation and proliferation, suppressing immune responses against cancer cells and contributing to immune evasion. Blocking the PD-1/PD-L1 interaction with therapeutic antibodies enhances T cell activity, making PD-1 inhibitors a promising approach in cancer immunotherapy.

    Synonyms

    Programmed cell death protein 1, CD279

  • Uniprot ID

    NP_005009.2

    Sequence Note

    Met1-Gln167

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human PD-1.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.