Leadgene Leadgene
Mouse IL-6R, His Tag, CHO
Catalog Number

LDG137PMM

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  • Specifications
    • Species of Origin

      Mouse

      Expression system

      CHO

    • Affinity Tag

      His Tag (C-term)

      Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >90% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 40.1 kDa.
      The protein migrates as 50-75 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin level

      <0.1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      Interleukin-6 receptor subunit alpha (IL-6R, also known as CD126) is a membrane glycoprotein that binds IL-6 and mediates signal transduction through its association with gp130. IL-6R plays a critical role in immune regulation, inflammation, and hematopoiesis, and is implicated in various pathological conditions including autoimmune diseases, cancers, and cardiovascular disorders. The soluble form (sIL-6R) extends IL-6 responsiveness to cells lacking membrane-bound IL-6R.

      Synonyms

      IL6R, Interleukin-6 receptor alpha chain, CD126 antigen, gp80, soluble IL-6 receptor, IL-6RA, cytokine receptor family member 18

    • Uniprot ID

      P22272

      Sequence Note

      Met1-Glu357

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant Mouse IL-6R protein.

    SDS-PAGE analysis of recombinant Mouse IL-6R protein.

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  • Datasheet & Documents
    MSDS
    Manual
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Disclaimer:For Research Use or Further Manufacturing Only.

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