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Catalog Number

LDG114PMM

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Specifications
- Species of Origin
  
  Mouse
  
  Expression system
  
  CHO
- Affinity Tag
  
  His Tag (C-term)
  
  Buffer
  
  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
- Purity
  
  >95% as determined by SDS-PAGE analysis.
  
  Molecular weight
  
  The protein has a calculated MW of 20.5 kDa.
  The protein migrates as 15-35 kDa under reducing condition (SDS-PAGE analysis).
- Activity
  
  Measured by its ability to bind human TRAIL in functional ELISA. Immobilized Recombinant human TRAIL Protein at 10 μg/mL (100 μL/well) can bind Recombinant Mouse DR5 Protein.
  
  Endotoxin level
  
  <0.1 EU per 1 μg of the protein by the LAL method.
- Form
  
  Lyophilized
Background
- Background
  
  Death receptor 5 (DR5), also known as TRAIL-R2, is a member of the tumor necrosis factor receptor superfamily. It binds to the TNF-related apoptosis-inducing ligand (TRAIL) and mediates apoptosis in target cells. DR5 is involved in immune surveillance and the elimination of cancer cells. In mice, DR5 expression and function are studied to understand its role in tumor biology and potential therapeutic applications.
  
  Synonyms
  
  Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, MK, CD262
- Uniprot ID
  
  Q9QZM4
  
  Sequence Note
  
  Asn53 - Lys180
Instruction
- Reconstitution
  
  It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
  
  Shipping
  
  The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
- Stability & Storage
  
  This product is stable after storage at:
  - -20°C for 12 months in lyophilized state from date of receipt.
  - -20°C or -80°C for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
Image

HPLC analysis of recombinant Mouse DR5, His Tag, CHO.
The purity of Mouse DR5 Protein is greater than 95% as determined by RP-HPLC.

Activity analysis of recombinant Mouse DR5, His Tag, CHO.
Measured by its ability to bind human TRAIL in functional ELISA. Immobilized Recombinant human TRAIL Protein at 10 μg/mL (100 μL/well) can bind Recombinant Mouse DR5 Protein.

SDS-PAGE analysis of recombinant mouse DR5.

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Datasheet & Documents

Datasheet

MSDS

Manual

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