Human TIM-3, His Tag, CHO

Catalog Number

LDG051PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    CHO

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 23.1 kDa.
    The protein migrates as 25-45 kDa under reducing condition due to glycosylation (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    T-cell immunoglobulin and mucin-domain containing protein 3 (TIM-3), encoded by HAVCR2, is an inhibitory immune checkpoint receptor expressed on T cells, NK cells, and other immune subsets. TIM-3 plays a critical role in regulating T cell exhaustion, immune tolerance, and inflammatory responses. In cancer, elevated TIM-3 expression contributes to tumor immune evasion and resistance to immune checkpoint therapy. TIM-3 is therefore widely studied in immunology and cancer research as a key regulator of immune signaling and a promising immuno-oncology target.

    Synonyms

    CD366, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, HAVCR2, T-cell membrane protein 3, Hepatitis A virus cellular receptor 2, Immune checkpoint receptor TIM-3

  • Uniprot ID

    Q8TDQ0

    Sequence Note

    Ser22-Arg200

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant Human TIM-3 protein.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.