Human SLAMF7, His Tag, HEK293

Catalog Number

LDG040PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

  • Purity

    >85% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 23.2 kDa.
    The protein migrates as 30-40 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measured by its ability to bind Human SLAMF7 Antibody in functional ELISA. Immobilized Recombinant human SLAMF7 Protein at 2 μg/mL (50 μL/well) can bind Human SLAMF7 Antibody.

    Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    SLAMF7, or Signaling Lymphocytic Activation Molecule Family member 7, is a cell surface receptor protein primarily expressed on natural killer (NK) cells, a type of immune cell, as well as on certain subsets of T cells and dendritic cells. It plays a significant role in immune cell activation and regulation. SLAMF7 is involved in various cellular processes, including cell adhesion, cytokine production, and cytotoxicity. Its interaction with its ligand, SLAMF7, or CS1, mediates the activation of NK cells and promotes their cytotoxic function against target cells, such as tumor cells. Additionally, SLAMF7 has emerged as a promising target for immunotherapy in cancer treatment, with monoclonal antibody therapies specifically targeting SLAMF7 showing efficacy in multiple myeloma and other hematologic malignancies.

    Synonyms

    CD2 subset 1, CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, Novel Ly9, Protein 19A, CD319

  • Uniprot ID

    GenBank: AAH27867.1

    Sequence Note

    Met1-Met226

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant Human SLAMF7.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.