Species of Origin
His-SUMO Tag (N-term)
Please refer to the product label.
Liquid. Phosphate buffered saline, pH 7.4.
>95% as determined by SDS-PAGE analysis.
The protein has a calculated MW of 46.8 kDa.
The protein migrates as 62-68 kDa under reducing condition (SDS-PAGE analysis).
R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The ED₅₀ for this effect is 1-3 μg/mL.
<1 EU per 1 μg of the protein by the LAL method.
R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/ 6), subsequent clearing negative regulators ZNRF3 /RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.
Roof plate-specific spondin-1, hRspo1
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long-term storage.
Stability & Storage
This product is stable after storage at:
- -80°C for long-term storage under sterile conditions.
Avoid repeated free-thaw cycles.
SDS-PAGE analysis of recombinant human R-Spondin 1.1/1
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Datasheet & Documents1/1
Disclaimer：For Research Use Only. Not for use in diagnostic or therapeutic procedures.