Human PDGFR Alpha, His Tag, HEK293

More Images

Catalog Number

LDG039PHM

Datasheet

More Documents

Loading package & price...

COA下載

• Specifications

  • Species of Origin

    Human

    Expression system

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

  • Purity

    >85% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 62 kDa.
    The protein migrates as 65-100 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    PDGFR Alpha, short for Platelet-Derived Growth Factor Receptor Alpha, is a transmembrane tyrosine kinase receptor protein encoded by the PDGFRA gene. It plays a crucial role in cell growth, development, and wound healing processes by binding with platelet-derived growth factors (PDGFs). Activation of PDGFR Alpha triggers various intracellular signaling pathways, including the Ras/MAPK pathway and the PI3K/Akt pathway, regulating cell proliferation, survival, and migration. Dysregulation of PDGFR Alpha signaling has been implicated in several diseases, including cancer and fibrotic disorders, making it a potential therapeutic target for drug development.

    Synonyms

    Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2 (PDGFR-2)

  • Uniprot ID

    P16234

    Sequence Note

    Met1-Ala528

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  HPLC analysis of recombinant Human PDGFR Alpha, His Tag, HEK293.
  The purity of Human PDGFR Alpha Protein is greater than 95% as determined by RP-HPLC.

  SDS-PAGE analysis of recombinant Human PDGFR Alpha.

  1

  /

  2

  Total   (2)

• Review

  

  Help others learn more about this product. Use the link below to share your experience.

  Submit a Review

• Publication

  

  There are currently no publications. Use the link below to let us know.

  Submit a Publication

• Datasheet & Documents

  Datasheet

  MSDS

  Manual

  1

  /

  1

Disclaimer：For Research Use or Further Manufacturing Only.