Human PCSK9, His Tag, CHO

Catalog Number

LDG037PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    CHO

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

  • Purity

    >85% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 71.86 kDa.
    The protein migrates as 55-60 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene. It plays a critical role in regulating cholesterol levels by binding to low-density lipoprotein receptors (LDLRs) on the surface of liver cells, promoting their degradation and reducing LDL cholesterol clearance from the bloodstream. Elevated PCSK9 levels are associated with increased LDL cholesterol levels and a higher risk of cardiovascular disease. Inhibiting PCSK9 function with monoclonal antibodies or small molecule inhibitors has emerged as an effective therapeutic strategy for lowering LDL cholesterol levels and reducing cardiovascular risk. PCSK9 inhibitors block the interaction between PCSK9 and LDLRs, leading to increased LDLR expression and enhanced LDL cholesterol clearance from the blood.

    Synonyms

    Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1 (NARC-1), Proprotein convertase 9 (PC9), Subtilisin/kexin-like protease PC9

  • Uniprot ID

    Q8NBP7

    Sequence Note

    Met1-Gln692

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant Human PCSK9.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.