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Leadgene Leadgene
Human NRG1 Protein, Tag Free, E. coli
Catalog Number

LDG178PHE

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  • Specifications
    • Species of Origin

      Human

      Expression system

      Escherichia coli

    • Affinity Tag

      Tag Free

      Buffer

      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 24.29 kDa.
      The protein migrates as 28-30 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin level

      <1 EU per 1 μg of the protein by the LAL method.

      Form

      Lyophilized

  • Background
    • Background

      Neuregulin-1 (NRG-1, also called heuregulin1 or neu differentiation factor) is a glycoprotein that belongs to the neuregulins family. Structurally, Neuregulin-1 harbors tissue-specific N terminal sequence, followed by immunoglobulin-like (Ig-like) domains, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. Neuregulin-1 exerts its actions upon engagement of its EGF-like domain to the extracellular binding region of HER RTK family members (EGFR, HER2, HER3, and HER4), subsequently leading to receptor dimerization which activates a variety of signal pathways such as MAPK-ERK and PI3K-AKT pathways. These signal cascades are essential for regulating cardiac development, neuronal differentiation, neuromuscular synapses formation, and stem cell proliferation.

      Synonyms

      Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin (HRG), Neu differentiation factor, Sensory and motor neuron-derived factor

    • Uniprot ID

      #Q02297

      Sequence Note

      Ser20-Lys241

  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

      Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of human NRG1 protein.

    SDS-PAGE analysis of human NRG1 protein.

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  • Datasheet & Documents
    MSDS
    Manual
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