Leadgene Leadgene
Human NF-L, His-SUMO Tag, E. coli
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  • Specifications
    • Species of Origin


      Expression system

      Escherichia coli

    • Affinity Tag

      His-SUMO Tag (N-term)


      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 73.91 kDa.
      The protein migrates as 75 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin level

      <0.1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      Neurofilaments (NF) are assembled as heteropolymers, found exclusively in neurons, and serve as axonal scaffolding. They are composed of three subunits, including NF-L (68 kDa), NF-M (95 kDa), and NF-H (115 kDa), that are essential for axonal growth and maintenance. Elevated NF-L levels in serum and CSF (cerebrospinal fluid) have been correlated with axonal damage in Multiple Sclerosis patients, serving as a prognostic marker. In addition, plasma NF-L concentrations were highly significantly higher in patients with Alzheimer’s disease.


      68 kDa neurofilament protein, Neurofilament triplet L protein

    • Uniprot ID

      # P07196

      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant human NF-L.

    SDS-PAGE analysis of recombinant human NF-L.

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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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