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Species of Origin
Human
Expression system
CHO
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Affinity Tag
His Tag (C-term)
Buffer
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
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Purity
>95% as determined by SDS-PAGE analysis.
Molecular weight
The protein has a calculated MW of 49.5 kDa.
The protein migrates as 58-75 kDa under reducing condition (SDS-PAGE analysis). -
Endotoxin level
<0.1 EU per 1 μg of the protein by the LAL method.
Form
Lyophilized
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Specifications
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Background
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Background
Guanylate cyclase C (GUCY2C) is a receptor primarily expressed in intestinal epithelial cells. It binds endogenous ligands like guanylin and uroguanylin, as well as bacterial heat-stable enterotoxins. Activation of GUCY2C regulates fluid and electrolyte secretion in the gut and maintains intestinal barrier function. It is also explored as a biomarker and therapeutic target in colorectal cancer.
Synonyms
Guanylyl cyclase C, GC-C, EC:4.6.1.2, Heat-stable enterotoxin receptor, STA receptor, hSTAR, Intestinal guanylate cyclase
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Uniprot ID
P25092
Sequence Note
Ser24-Gln430
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Instruction
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Reconstitution
It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.
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Stability & Storage
This product is stable after storage at:
- -20°C for 12 months in lyophilized state from date of receipt.
- -20°C or -80°C for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
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Image
![SDS-PAGE analysis of recombinant Human GUCY2C.]()
SDS-PAGE analysis of recombinant Human GUCY2C.
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Publication
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Datasheet & Documents
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Disclaimer：For Research Use or Further Manufacturing Only.
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