Leadgene Leadgene
Human GM2A, His Tag, HEK293
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  • Specifications
    • Species of Origin


      Expression system

      HEK293 cell

    • Affinity Tag

      His Tag (C-term)


      Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

    • Purity

      >95% as determined by SDS-PAGE analysis.

      Molecular weight

      The protein has a calculated MW of 21.92 kDa.
      The protein migrates as 24 kDa under reducing condition (SDS-PAGE analysis).

    • Endotoxin level

      <1 EU per 1 μg of the protein by the LAL method.



  • Background
    • Background

      The human GM2A protein, also known as GM2 ganglioside activator protein, is a small glycoprotein that plays a crucial role in lipid metabolism. It is primarily expressed in lysosomes, where it binds to and facilitates the breakdown of a type of lipid molecule known as GM2 ganglioside. This lipid molecule is typically found in high concentrations in the nervous system and plays a key role in neural signaling. Deficiencies in the GM2A protein have been linked to a rare genetic disorder known as GM2 gangliosidosis, which can lead to the accumulation of GM2 ganglioside in the brain and nervous system. This can result in severe neurological symptoms, including developmental delays, seizures, and loss of motor function.
      Recent research has also suggested that the GM2A protein may have potential therapeutic applications in the treatment of certain types of cancer. Studies have shown that the protein can help to induce apoptosis (cell death) in cancer cells, and may be able to enhance the effectiveness of certain chemotherapy drugs. Overall, the human GM2A protein plays a critical role in lipid metabolism and has important implications for a range of health conditions, from rare genetic disorders to cancer.


      Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3

    • Uniprot ID


      Sequence Note


  • Instruction
    • Reconstitution

      It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.


      The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

    • Stability & Storage

      This product is stable after storage at:

      • -20°C for 12 months in lyophilized state from date of receipt.
      • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

      Avoid repeated freeze/thaw cycles.

  • Image
    SDS-PAGE analysis of recombinant human GM2A.

    SDS-PAGE analysis of recombinant human GM2A.

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  • Datasheet & Documents

Disclaimer:For Research Use or Further Manufacturing Only.

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