Human CGRP, His Tag, HEK293

Catalog Number

LDG038PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

  • Purity

    >85% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 13.6 kDa.
    The protein migrates as 10-15 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    CALCA, also known as calcitonin gene-related peptide alpha (CGRP-alpha), is a neuropeptide encoded by the CALCA gene. It is widely distributed in the central and peripheral nervous systems and plays a crucial role in nociceptive signaling, vasodilation, and neurogenic inflammation. CALCA exists in multiple isoforms, including α, β, and γ-CGRP, with α-CGRP being the predominant form in humans. Elevated levels of CALCA, particularly α-CGRP, are implicated in migraine pathophysiology, where it contributes to pain transmission and vasodilation. Additionally, CALCA is involved in various physiological processes, including cardiovascular regulation, gastrointestinal motility, and bone metabolism. Targeting CALCA or its receptors has therapeutic potential for the treatment of migraine, pain disorders, and other conditions influenced by neuropeptide signaling.

    Synonyms

    Calcitonin, CALCA

  • Uniprot ID

    NCBI: NP_001732.1

    Sequence Note

    Met1-Asn141

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant Human CGRP.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.