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Leadgene Leadgene
Anti-HMGB1 Antibody [Clone B1511]
Catalog Number

LDG0038YA

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  • Overview

    Description

    High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin. HMGB1 is a non-histone nuclear protein with a dual function. In the nucleus, HMGB1 is a DNA binding protein that associates with chromatin and can bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Outside the cell, HMGB1 displays cytokine activity and can promote inflammation, serving as a mediator in models of shock and arthritis.

    Product Note

    Recommended dilution factor:
    ELISA: 1:5000-20000
    WB: 1:1000-10000

    Note: Working dilution for specific application should be determined by the investigator to obtain the best conditions.

  • Specifications
    • Host

      Mouse

      Clonality

      Monoclonal

    • Isotype

      IgM

      Clone Name

      clone B1511

    • Immunogen

      HMGB1

      Reactivity

      Human

    • Application

      ELISA, WB, IFA, FACS

      Conjugation

      Unconjugated

    • Concentration

      0.5 mg/mL

      Buffer

      Phosphate Buffered Saline, pH 7.4.

    • Specificity

      Recognizes HMGB1 protein and do not cross-react with HMGB2.

      Form

      Liquid

  • Instruction
    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at 2-8°C for long term storage.

      Stability & Storage

      This product is stable after storage at:

      • 2-8°C for 6 months under sterile conditions from date of receipt.

      Briefly centrifuge vials before opening.

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  • Datasheet & Documents
    MSDS
    Manual
    1
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    1

Disclaimer:For Research Use or Further Manufacturing Only.

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