説明
Beta-amyloid (Aβ) is one of the intrinsically disordered proteins (IDPs) involved in Alzheimer's disease (AD) pathogenesis. This peptide derives from the sequential cleavage of a transmembrane glycoprotein, amyloid precursor protein (APP), by beta secretase and gamma secretase. The abnormal metabolism of APP result in excessive accumulation of Aβ, and triggers neurofibrillary tangles, oxidative stress, microglial activation, synaptic dysfunction, synaptic loss and the inflammatory response.
製品ノート
Recommended dilution factor:
ELISA: 1:5000-20000
WB:1: 1000-5000
Note: Working dilution for specific application should be determined by the investigator to obtain the best conditions.