Anti-HMGB1 Antibody [Clone B1511]

Catalog Number

LDG0038YA

Datasheet

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• Overview

  Description

  High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin. HMGB1 is a non-histone nuclear protein with a dual function. In the nucleus, HMGB1 is a DNA binding protein that associates with chromatin and can bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Outside the cell, HMGB1 displays cytokine activity and can promote inflammation, serving as a mediator in models of shock and arthritis.

  Product Note

  Recommended dilution factor:
  ELISA: 1:5000-20000
  WB: 1:1000-10000
  
  Note: Working dilution for specific application should be determined by the investigator to obtain the best conditions.

• Specifications

  • Host

    Mouse

    Clonality

    Monoclonal

  • Isotype

    IgM

    Clone Name

    clone B1511

  • Immunogen

    HMGB1

    Reactivity

    Human

  • Application

    ELISA, WB, IFA, FACS

    Conjugation

    Unconjugated

  • Concentration

    0.5 mg/mL

    Storage Buffer

    Phosphate Buffered Saline, pH 7.4.

  • Specificity

    Recognizes HMGB1 protein and do not cross-react with HMGB2.

    Form

    Liquid

• Instruction

  • Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at 2-8°C for long term storage.

    Stability & Storage

    This product is stable after storage at:

    • 2-8°C for 6 months under sterile conditions from date of receipt.

    Briefly centrifuge vials before opening.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.